Science Feeds

Journal of Medicinal Chemistry

• [ASAP] Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors
  by Chen-Xi Wang, Zi-Lin Zhang, Qi-Kun Yin, Jia-Li Tu, Jia-En Wang, Yao-Hao Xu, Yong Rao, Tian-Miao Ou, Shi-Liang Huang, Ding Li, Hong-Gen Wang, Qing-Jiang Li, Jia-Heng Tan, Shuo-Bin Chen*, and Zhi-Shu Huang*
• [ASAP] Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS? <subtitle>Miniperspective</subtitle>
  by Brice Korkmaz*†, Adam Lesner‡, Sylvain Marchand-Adam†§, Celia Moss∥, and Dieter E. Jenne⊥
• [ASAP] MicroRNA-Based Multitarget Approach for Alzheimer’s Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis
  by Moustafa T. Gabr*† and Simone Brogi‡
• [ASAP] Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases
  by Bin Ma*, Tonika Bohnert, Kevin L. Otipoby†, Eric Tien, Million Arefayene, Judy Bai, Bekim Bajrami, Eris Bame, Timothy R. Chan‡, Michael Humora§, J. Michael MacPhee∥, Douglas Marcotte⊥, Devangi Mehta#, Claire M. Metrick, George Moniz, Evelyne Polack, Urjana Poreci, Annick Prefontaine, Sarah Sheikh∞, Patricia Schroeder⊥, Karen Smirnakis, Lei Zhang, Fengmei Zheng, and Brian T. Hopkins*
• [ASAP] Structure–Activity Relationships of Daptomycin Lipopeptides
  by John A. Karas†, Glen P. Carter‡, Benjamin P. Howden‡, Adrianna M. Turner‡, Olivia K. A. Paulin†, James D. Swarbrick†, Mark. A. Baker§, Jian Li*∥, and Tony Velkov*†
• [ASAP] Exploration of Alternative Scaffolds for P2Y₁₄ Receptor Antagonists Containing a Biaryl Core
  by Young-Hwan Jung†⊥, Jinha Yu†⊥#, Zhiwei Wen†, Veronica Salmaso†, Tadeusz P. Karcz‡§, Ngan B. Phung†, Zhoumou Chen∥, Sierra Duca†, John M. Bennett†, Steven Dudas†, Daniela Salvemini∥, Zhan-Guo Gao†, Donald N. Cook‡, and Kenneth A. Jacobson*†
• [ASAP] Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies
  by Brianna D. Mackie†, Dongxing Chen‡, Guangping Dong‡, Cheng Dong§, Haley Parker∥, Christine E. Schaner Tooley∥, Nicholas Noinaj⊥, Jinrong Min§, and Rong Huang*†‡
• [ASAP] Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis
  by Hongyi Zhao†, Bin Wang§, Lei Fu§, Gang Li†, Haijia Lu†, Yuke Liu‡, Li Sheng‡, Yan Li‡, Baoxi Zhang⊥, Yang Lu⊥, Chen Ma∥, Haihong Huang*†, Dongfeng Zhang*†, and Yu Lu*§
• [ASAP] Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia
  by Xiaojin Zhang*†§⊥, Yonghua Lei†‡⊥, Tianhan Hu†‡, Yue Wu†‡, Zhihong Li§, Zhensheng Jiang†‡, Changyong Yang∥, Lianshan Zhang∥, and Qidong You*†‡
• [ASAP] Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
  by Rosa María Rodríguez Sarmiento*, Caterina Bissantz, Johan Bylund, Anja Limberg, Werner Neidhart, Roland Jakob-Roetne, Lisha Wang, and Karlheinz Baumann

ACS Medicinal Chemistry Letters

• [ASAP] Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
  by Rachel L. Palte*†, Sebastian E. Schneider*†, Michael D. Altman†, Robert P. Hayes§, Shuhei Kawamura‡, Brian M. Lacey∥, My Sam Mansueto∥, Michael Reutershan‡, Phieng Siliphaivanh‡, Christopher Sondey∥, Haiyan Xu∥, Zangwei Xu∥, Yingchun Ye‡, and Michelle R. Machacek‡
• [ASAP] Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia
  by David R. Witty*†, Giuseppe Alvaro†§, Dominique Derjean†, Gerard M. P. Giblin†, Kevin Gunn†, Charles Large†§, David T. Macpherson†, Valerie Morisset†, Davina Owen†, Joanne Palmer†, Francois Rugiero†, Simon Tate†, Christopher A. Hinckley‡, and Himanshu Naik‡
• [ASAP] Automation of Synthesis in Medicinal Chemistry: Progress and Challenges
  by Elizabeth Farrant*
• [ASAP] New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase
  by Yuta Tanaka*†, Osamu Kurasawa†, Akihiro Yokota†, Michael G. Klein‡, Bunnai Saito†, Shigemitsu Matsumoto†, Masanori Okaniwa†, Geza Ambrus-Aikelin‡, Noriko Uchiyama†, Daisuke Morishita†, Hiromichi Kimura†, and Shinichi Imamura†
• [ASAP] Virtual Screening for Ligand Discovery at the σ₁ Receptor
  by Daniel A. Greenfield†∥, Hayden R. Schmidt†∥⊥, Meredith A. Skiba†, Michael D. Mandler‡, Jacob R. Anderson†, Piotr Sliz*†§, and Andrew C. Kruse*†
• [ASAP] Identification and Development of 1,4-Diaryl-1,2,3-triazolo-Based Ureas as Novel FLT3 Inhibitors
  by Jisheng Liu†ξ, Yuting Wang†ξ, Chen Chen†ξ, Zhengchao Tu†‡, Sihua Zhu†, Fengtao Zhou†, Hongfei Si†, Canhui Zheng*§, Zhang Zhang*†, and Qian Cai*†
• [ASAP] Fluorescent H₂ Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications
  by Sabrina Biselli*‡#, Inês Alencastre§⧫, Katharina Tropmann‡, Daniela Erdmann‡∇, Mengya Chen‡○, Timo Littmann‡□, André F. Maia§⊥, Maria Gomez-Lazaro§⧫, Miho Tanaka†, Takeaki Ozawa†, Max Keller‡, Meriem Lamghari§⧫, Armin Buschauer‡∥, and Günther Bernhardt*‡
• [ASAP] Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein
  by Thomas R. Lane and Sean Ekins*
• [ASAP] Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation
  by Jonathan H. Shrimp†, Yihang Jing†, Supuni Thalalla Gamage†, Kathryn M. Nelson‡, Joseph Han§, Keri M. Bryson†, David C. Montgomery†, Justin M. Thomas†, Kellie D. Nance†, Sunny Sharma∥, Stephen D. Fox⊥, Thorkell Andressen⊥, Wilson R. Sinclair†, Hong Wu#, Abdellah Allali-Hassani#, Guillermo Senisterra#, Masoud Vedadi#, Denis Lafontaine∇, Jayme L. Dahlin○, Ronen Marmorstein§□, Michael A. Walters‡, and Jordan L. Meier*†
• [ASAP] The Advent of Generative Chemistry
  by Quentin Vanhaelen*†, Yen-Chu Lin†‡, and Alex Zhavoronkov†

Journal of Natural Products

• [ASAP] Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of <italic toggle="yes">Podocarpus imbricatus</italic>
  by Bin Zhou†‡, Yu-Hao Ren†‡, Ying-Shan Han§, Thibault Mesplède§, and Jian-Min Yue*†‡
• [ASAP] Bioactive Lignans from <italic toggle="yes">Hypoestes aristata</italic>
  by Tshifhiwa Ramabulana†, Luki-Marié Scheepers†, Thirshen Moodley†, Vinesh J. Maharaj†, André Stander‡, Ntombenhle Gama§, Daneel Ferreira⊥, Molahlehi S. Sonopo∥, and Mamoalosi A. Selepe*†
• [ASAP] Viennamycins: Lipopeptides Produced by a <italic toggle="yes">Streptomyces</italic> sp.
  by Paulina Bekiesch†, Martin Zehl‡, Elizabeth Domingo-Contreras§, Jesús Martín§, Ignacio Pérez-Victoria§, Fernando Reyes§, Arthur Kaplan†, Christian Rückert⊥, Tobias Busche⊥, Jörn Kalinowski⊥, and Sergey B. Zotchev*†
• [ASAP] Biosynthesis of the Fairy Chemicals, 2-Azahypoxanthine and Imidazole-4-carboxamide, in the Fairy Ring-Forming Fungus <italic toggle="yes">Lepista sordida</italic>
  by Akinobu Ito†‡, Jae-Hoon Choi†§∧, Hirohide Takemura†‡, Mihaya Kotajima†, Jing Wu∧, Shinji Tokuyama§, Hirofumi Hirai†§∧, Tomohiro Asakawa⊥, Hitoshi Ouchi#, Makoto Inai#, Toshiyuki Kan#, and Hirokazu Kawagishi*†§∧
• [ASAP] Heimiomycins A–C and Calamenens from the African Basidiomycete <italic toggle="yes">Heimiomyces</italic> sp.
  by Tian Cheng†‡⊥, Clara Chepkirui†‡⊥, Cony Decock§, Josphat C. Matasyoh∥, and Marc Stadler*†‡
• [ASAP] Glycosides and Glycoconjugates of the Diterpenoid Isosteviol with a 1,2,3-Triazolyl Moiety: Synthesis and Cytotoxicity Evaluation
  by Olga V. Andreeva, Bulat F. Garifullin, Radmila R. Sharipova, Irina Yu. Strobykina, Anastasiya S. Sapunova, Alexandra D. Voloshina, Mayya G. Belenok, Alexey B. Dobrynin, Leysan R. Khabibulina, and Vladimir E. Kataev*
• [ASAP] Synthesis of (−)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis
  by Manish Walia†⊥, Christiana N. Teijaro†⊥, Alex Gardner†⊥, Thi Tran†, Jinfeng Kang†, Senzhi Zhao†, Sarah E. O’Connor‡, Vincent Courdavault§, and Rodrigo B. Andrade*†
• [ASAP] Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
  by Olga Luzina‡, Alexander Filimonov‡§, Alexandra Zakharenko†, Arina Chepanova†, Olga Zakharova†, Ekaterina Ilina†, Nadezhda Dyrkheeva†, Galina Likhatskaya⊥, Nariman Salakhutdinov‡§, and Olga Lavrik*†§
• [ASAP] Structure–Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity
  by Noriyuki Natsume†, Kaori Ozaki†, Daisuke Nakajima‡, Satoshi Yokoshima‡, and Toshiaki Teruya*†§
• [ASAP] Generation of Stilbene Antimicrobials against Multiresistant Strains of <italic toggle="yes">Staphylococcus aureus</italic> through Biotransformation by the Enzymatic Secretome of <italic toggle="yes">Botrytis cinerea</italic>
  by Davide Righi†¶□, Robin Huber†¶□, Alexey Koval‡, Laurence Marcourt†¶, Sylvain Schnee§, Anaïs Le Floch†¶, Verena Ducret∥, Remo Perozzo†¶, Concetta C. de Ruvo†¶, Nicole Lecoultre§, Emilie Michellod§, Samad N. Ebrahimi△, Elisabeth Rivara-Minten†¶, Vladimir L. Katanaev‡∇, Karl Perron∥, Jean-Luc Wolfender†¶, Katia Gindro*§, and Emerson F. Queiroz*†¶