Science Feeds

Journal of Medicinal Chemistry

• [ASAP] Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development
  by Hexiang Wang, Bo Ren, Ye Liu, Beibei Jiang, Yin Guo, Min Wei, Lusong Luo, Xianzhao Kuang, Ming Qiu, Lei Lv, Hong Xu, Ruipeng Qi, Huibin Yan, Dexu Xu, Zhiwei Wang, Chang-Xin Huo, Yutong Zhu, Yuan Zhao, Yiyuan Wu, Zhen Qin, Dan Su, Tristin Tang, Fan Wang, Xuebing Sun, Yingcai Feng, Hao Peng, Xing Wang, Yajuan Gao, Yong Liu, Wenfeng Gong, Fenglong Yu, Xuesong Liu, Lai Wang, and Changyou Zhou
• [ASAP] Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment
  by Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Yingfeng Tu, Jingxuan Chen, Shuwen Liu, Xuchao Yang, and Jianjun Chen
• [ASAP] Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity
  by Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang, and Danqing Song
• [ASAP] Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases
  by Wooseok Han, Yu Ding, Zheng Chen, John L. Langowski, Cornelia Bellamacina, Alice Rico, Gisele A. Nishiguchi, Jiong Lan, Gordana Atallah⧫, Mika Lindvall, Song Lin, Richard Zang, Paul Feucht, Tatiana Zavorotinskaya, Yumin Dai, Pablo Garcia, and Matthew T. Burger
• [ASAP] Discovery of a Potent and Selective PI3Kδ Inhibitor (<italic toggle="yes">S</italic>)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4<italic toggle="yes">H</italic>-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
  by Manojkumar R. Shukla, Sukanya Patra, Mahip Verma, Gayathri Sadasivam, Nirmal Jana, Sachin J. Mahangare, Prashant Vidhate, Dipak Lagad, Anand Tarage, Murthy Cheemala, Chaitanya Kulkarni, Shankar Bhagwat, Vinod D. Chaudhari, Majid Sayyed, Vipul Pachpute, Ramesh Phadtare, Gopal Gole, Samiron Phukan, Brahmam Sunkara, Charudatt Samant, Manisha Shingare, Aditya Naik, Sneha Trivedi, Ajit Kumar Marisetti, Madhusudhan Reddy, Milind Gholve, Nilesh Mahajan, Sudeep Sabde, Vinod Patil, Dipak Modi, Maneesh Mehta, Prashant Nigade, Kaustubh Tamane, Swati Tota, Hemant Goyal, Harish Volam, Shashikant Pawar, Prajakta Ahirrao, Lal Dinchhana, Sadanand Mallurwar, Atul Akarte, Anand Bokare, Rupesh Kanhere, Neetinkumar Reddy, Sarita Koul, Manoj Dandekar, Minakshi Singh, Peter R. Bernstein, Lakshmi Narasimham, Mandar Bhonde, Jayasagar Gundu, Rajan Goel, Sanjeev Kulkarni, Sharad Sharma, Rajender Kumar Kamboj, and Venkata P. Palle
• [ASAP] Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches
  by Hai-Yun Xiao, Ning Li, James J.-W. Duan, Bin Jiang, Zhonghui Lu, Khehyong Ngu, Joseph Tino, Lisa M. Kopcho, Hao Lu, Jing Chen, Andrew J. Tebben, Steven Sheriff, ChiehYing Y. Chang, Joseph Yanchunas, Jr., Deepa Calambur, Mian Gao, David J. Shuster, Vojkan Susulic, Jenny H. Xie, Victor R. Guarino, Dauh-Rurng Wu, Kurt R. Gregor, Christine B. Goldstine, John Hynes, Jr., John E. Macor, Luisa Salter-Cid, James R. Burke, Patrick J. Shaw, and T. G. Murali Dhar
• [ASAP] Global Assessment of Substituents on the Basis of Analogue Series
  by Kosuke Takeuchi, Ryo Kunimoto, and Jürgen Bajorath
• [ASAP] Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors
  by Marta Serafini, Celia Cordero-Sanchez, Rosanna Di Paola, Irene P. Bhela, Silvio Aprile, Beatrice Purghè, Roberta Fusco, Salvatore Cuzzocrea, Armando A. Genazzani, Beatrice Riva, and Tracey Pirali
• [ASAP] Discovery of Potent, Highly Selective, and <italic toggle="yes">In Vivo</italic> Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing
  by Carole Pissot Soldermann, Oliver Simic, Martin Renatus, Paulus Erbel, Samu Melkko, Markus Wartmann, Marc Bigaud, Andreas Weiss, Paul McSheehy, Ralf Endres, Paulo Santos, Jutta Blank, Ansgar Schuffenhauer, Guido Bold, Nicole Buschmann, Thomas Zoller, Eva Altmann, Paul W. Manley, Ina Dix, Elisabeth Buchdunger, Julien Scesa, Jean Quancard, Achim Schlapbach, Frédéric Bornancin, Thomas Radimerski, and Catherine H. Régnier
• [ASAP] Drug Development in Channelopathies: Allosteric Modulation of Ligand-Gated and Voltage-Gated Ion Channels
  by Yanyun Zhang, Ke Wang, and Zhiyi Yu

ACS Medicinal Chemistry Letters

• [ASAP] Carboxamides as Modulators of Sodium Channels
  by Benjamin E. Blass
• [ASAP] Novel 2-Aryloxazoline Compounds Exhibit an Inhibitory Effect on <italic toggle="yes">Candida</italic> spp., Including Antifungal-Resistant Isolates
  by Luis M. Z. Argomedo, Vinicius M. Barroso, Cristiane S. Barreiro, Mariana P. Darbem, Kelly Ishida, and Hélio A. Stefani
• [ASAP] Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials
  by Shalini, Sumit Kumar, Mathieu Gendrot, Isabelle Fontaξ, Joel Mosnierξ, Nosipho CeleΔ, Paul AwoladeΔ, Parvesh SinghΔ, Bruno Pradinesξ, and Vipan Kumar
• [ASAP] Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity
  by Toghrul Almammadov, Gizem Atakan, Ozen Leylek, Gulnihal Ozcan, Gorkem Gunbas, and Safacan Kolemen
• [ASAP] Novel Potassium Channel Inhibitors
  by Benjamin E. Blass
• [ASAP] 2-Amino-N-heteroaryl-nicotimamides as Na_v1.8 Inhibitors
  by Benjamin E. Blass
• [ASAP] Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer
  by Robert B. Kargbo
• [ASAP] Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides
  by Nicholas A. Clanton, Shayne D. Hastings, Griffin B. Foultz, Julie A. Contreras, Samantha S. Yee, Hadi D. Arman, April L. Risinger, and Doug E. Frantz
• [ASAP] Novel Compounds as STING Modulators for Treating Hepatitis B Virus Infections
  by Ram W. Sabnis
• [ASAP] Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
  by Joey L. Methot, Abdelghani Achab, Matthew Christopher, Hua Zhou, Meredeth A. McGowan, B. Wesley Trotter, Xavier Fradera, Charles A. Lesburg, Peter Goldenblatt, Armetta Hill, Dapeng Chen, Karin M. Otte, Martin Augustin, Sanjiv Shah, and Jason D. Katz

Journal of Natural Products

• [ASAP] Phenolic Constituents of the Roots of <italic toggle="yes">Rhamnoneuron balansae</italic> with Senolytic Activity
  by Hyo-Moon Cho, Yae-Rin Lee, Ba-Wool Lee, Mi Zhang, Byeol Ryu, Du-Trong Nghiem, Ha-Thanh-Tung Pham, and Won-Keun Oh
• [ASAP] Bioactive Limonoids and Triterpenoids from the Fruits of <italic toggle="yes">Melia azedarach</italic>
  by Min Song, Jian Zhang, Ging Chan, Ying Hou, Xiu-Ping Chen, Xiao-Qi Zhang, Wen-Cai Ye, and Qing-Wen Zhang
• [ASAP] In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis
  by Rubén Martín-Escolano, Juan J. Guardia, Javier Martín-Escolano, Nuria Cirauqui, Antonio Fernández, Maria J. Rosales, Rachid Chahboun, Manuel Sánchez-Moreno, Enrique Alvarez-Manzaneda, and Clotilde Marín
• [ASAP] Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from <italic toggle="yes">Tacca chantrieri</italic>
  by Yue Yang, Qi Gong, Wei Wang, Ying-Le Mao, Xiao-Rong Wang, Sheng Yao, Hai-Yan Zhang, Chunping Tang, and Yang Ye
• [ASAP] 15β-Senecioyl-oxy-<italic toggle="yes">ent</italic>-kaur-16-en-19-oic Acid, a Diterpene Isolated from <italic toggle="yes">Baccharis lateralis</italic>, as Promising Oral Compound for the Treatment of Schistosomiasis
  by Deborah P. Sessa, Ana C. Mengarda, Paula E. Simplicio, Guilherme M. Antar, João Henrique G. Lago, and Josué de Moraes
• [ASAP] Structure Elucidation of the <italic toggle="yes">spiro</italic>-Polyketide Svalbardine B from the Arctic Fungal Endophyte <italic toggle="yes">Poaceicola</italic> sp. E1PB with Support from Extensive ESI-MS^{<italic toggle="yes">n</italic>} Interpretation
  by Fatimah Bebe M. Hussain, Amjad Ayad Qatran Al-Khdhairawi, Hong Kok Sing, Anis Low Muhammad Low, El Hassane Anouar, Noel F. Thomas, Siti Aisyah Alias□, Nurhuda Manshoor, and Jean-Frédéric F. Weber
• [ASAP] Linearolactone and Kaempferol Disrupt the Actin Cytoskeleton in <italic toggle="yes">Entamoeba histolytica</italic>: Inhibition of Amoebic Liver Abscess Development
  by José Antonio Velázquez-Domínguez, Verónica Ivonne Hernández-Ramírez, Fernando Calzada, Luis Varela-Rodríguez, Diana L. Pichardo-Hernández, Elihú Bautista, Mayra Herrera-Martínez, Rodrigo D. Castellanos-Mijangos, Audifas Salvador Matus-Meza, Bibiana Chávez-Munguía, and Patricia Talamás-Rohana
• [ASAP] Sesquiterpene Polygodial from <italic toggle="yes">Drimys brasiliensis</italic> (Winteraceae) Down-Regulates Implant-Induced Inflammation and Fibrogenesis in Mice
  by Bruno Antonio Ferreira, Anderson Ferraz Norton Filho, Simone Ramos Deconte, Tatiana Carla Tomiosso, Fernanda Thevenard, Silvia Passos Andrade, João Henrique Ghilardi Lago, and Fernanda de Assis Araújo
• [ASAP] An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures
  by Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R. O’Keefe, Susan L. Mooberry, and Robert H. Cichewicz
• [ASAP] Azodyrecins A–C: Azoxides from a Soil-Derived <italic toggle="yes">Streptomyces</italic> Species
  by Mario Wibowo, Charlotte H. Gotfredsen, Elisa Sassetti, Jette Melchiorsen, Mads Hartvig Clausen, Lone Gram, and Ling Ding