Science Feeds

Journal of Medicinal Chemistry

• [ASAP] Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus
  by Arun Kapoor#†, Ayan K. Ghosh#†, Michael Forman‡, Xin Hu§, Wenjuan Ye§, Noel Southall§, Juan Marugan§, Robert F. Keyes?, Brian C. Smith?, David J. Meyers?, Marc Ferrer§, and Ravit Arav-Boger*†?
• [ASAP] Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors
  by Simona Di Martino‡?, Piero Tardia‡?, Vincenzo Cilibrasi‡, Samantha Caputo‡, Marco Mazzonna‡, Debora Russo§, Ilaria Penna§, Natalia Realini‡, Natasha Margaroli‡, Marco Migliore‡, Daniela Pizzirani‡, Giuliana Ottonello?, Sine Mandrup Bertozzi?, Andrea Armirotti?, Duc Nguyen#, Ying Sun?, Ernesto R. Bongarzone#, Peter Lansbury?, Min Liu?, Renato Skerlj*??, and Rita Scarpelli*‡
• [ASAP] <italic toggle="yes">N</italic>-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
  by Daniele Piomelli*†‡§, Laura Scalvini?, Yannick Fotio†, Alessio Lodola?, Gilberto Spadoni?, Giorgio Tarzia?, and Marco Mor?
• [ASAP] Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds
  by Irene G. Salado†, Abhimanyu K. Singh‡#, Carlos Moreno-Cinos†, Guna Sakaine†?, Marco Siderius§, Pieter Van der Veken†, An Matheeussen?, Tiffany van der Meer§, Payman Sadek§, Sheraz Gul?, Louis Maes?, Geert-Jan Sterk§, Rob Leurs§, David Brown‡, and Koen Augustyns*†
• [ASAP] How We Think about Targeting RNA with Small Molecules
  by Matthew G. Costales, Jessica L. Childs-Disney, Hafeez S. Haniff, and Matthew D. Disney*
• [ASAP] Investigation of Inactive-State ? Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes
  by Antonios Drakopoulos†, Zsombor Koszegi‡, Yann Lanoisele´e‡, Harald Hu¨bner§, Peter Gmeiner§, Davide Calebiro*‡, and Michael Decker*†
• [ASAP] Drug Distribution in Living Cells via Label-Free Molecular Fingerprint
  by Samir F. El-Mashtoly*
• [ASAP] TREK Channel Family Activator with a Well-Defined Structure–Activation Relationship for Pain and Neurogenic Inflammation
  by Yunguang Qiu†§#, Lu Huang‡, Jie Fu†, Chenxia Han?, Jing Fang?, Ping Liao‡, Zhuo Chen‡, Yiqing Mo†, Peihua Sun?, Daqing Liao‡, Linghui Yang‡, Jing Wang‡, Qiansen Zhang†, Jin Liu‡, Feng Liu?, Tingting Liu?, Wei Huang?, Huaiyu Yang*†, and Ruotian Jiang*‡
• [ASAP] Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase
  by Buyun Tang†, Mykhaylo S. Frasinyuk‡§, Vimbai M. Chikwana†, Krishna K. Mahalingan†, Cynthia A. Morgan†, Dyann M. Segvich†, Svitlana P. Bondarenko§, Galyna P. Mrug‡§, Przemyslaw Wyrebek??, David S. Watt??#, Anna A. DePaoli-Roach†, Peter J. Roach†, and Thomas D. Hurley*†
• [ASAP] Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity
  by Verrill M. Norwood, IV†§, Ariana C. Brice-Tutt‡§, Shainnel O. Eans‡§, Heather M. Stacy‡§, Guqin Shi†§, Ranjala Ratnayake†§, James R. Rocca†?, Khalil A. Abboud?, Chenglong Li†§, Hendrik Luesch†§, Jay P. McLaughlin‡§, and Robert W. Huigens, III*†§

ACS Medicinal Chemistry Letters

• [ASAP] Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and <italic toggle="yes">In Vivo</italic> Activity in a Mood Disorder Model
  by Federica Prati†, Rosa Buonfiglio†, Guido Furlotti†, Claudia Cavarischia†, Giorgina Mangano†, Rossella Picollo†, Laura Oggianu†, Anna di Matteo†, Silvana Olivieri†, Graziella Bovi†, Pier Francesca Porceddu§, Angelo Reggiani§, Beatrice Garrone†, Francesco Paolo Di Giorgio†, and Rosella Ombrato*†
• [ASAP] Multiple <italic toggle="yes">in Vitro</italic> Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA
  by Elia Gamba†, Alice Sosic*†, Irene Saccone‡, Elisa Magli‡, Francesco Frecentese‡, and Barbara Gatto†
• [ASAP] Phenolic Compounds from <italic toggle="yes">Morus nigra</italic> Regulate Viability and Apoptosis of Pancreatic ß-Cells Possibly via SERCA Activity
  by Vladimir Heger†‡, Barbora Benesova†‡, Jana Viskupicova†, Magdalena Majekova†, Zoofishan Zoofishan§, Attila Hunyadi§, and Lubica Horakova*†
• [ASAP] Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells
  by Annalisa Romanelli†?, Giulia Stazi†, Rossella Fioravanti†?, Clemens Zwergel†‡, Elisabetta Di Bello†, Silvia Pomella#, Clara Perrone#?, Cecilia Battistelli?, Raffaele Strippoli??, Marco Tripodi??, Donatella del Bufalo§, Rossella Rota*#, Daniela Trisciuoglio*?§, Antonello Mai*†, and Sergio Valente*†
• [ASAP] Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors
  by Jessica Caciolla?†, Angelo Spinello?‡, Silvia Martini§, Alessandra Bisi†, Nadia Zaffaroni§, Silvia Gobbi*†, and Alessandra Magistrato*‡
• [ASAP] Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy
  by Matthew J. Mitcheltree*†‡, Derun Li*†‡, Abdelghani Achab†, Adam Beard†, Kalyan Chakravarthy§, Mangeng Cheng§, Hyelim Cho§a, Padmanabhan Eangoor?, Peter Fan?, Symon Gathiaka#, Hai-Young Kimß°, Charles A. Lesburg#, Thomas W. Lyons?, Theodore A. Martinot??, J. Richard Miller§, Spencer McMinn†, Jennifer O’Neil?d, Anandan Palani?, Rachel L. Palte#, Josep Sauri´°, David L. Sloman†, Hongjun Zhang†e, Jared N. Cumming†?, and Christian Fischer†
• [ASAP] Inhibition of Human Immunodeficiency Virus-1 Integrase by ß-Diketo Acid Coated Gold Nanoparticles
  by Vanna Sanna†, Mohamed Fathy Youssef§‡, Nicolino Pala§, Dominga Rogolino#, Mauro Carcelli#, Pankaj Kumar Singh§, Tino Sanchez°, Nouri Neamati*?, and Mario Sechi*§
• [ASAP] The Resurrection of Phenotypic Drug Discovery
  by Wayne E. Childers†, Khaled M. Elokely†‡§, and Magid Abou-Gharbia*†
• [ASAP] Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase
  by Rolando Cannalire†?, Kitti Wing Ki Chan#?, Maria Sole Burali†, Chin Piaw Gwee#, Sai Wang#, Andrea Astolfi†, Serena Massari†, Stefano Sabatini†, Oriana Tabarrini†, Eloise Mastrangelo§‡, Maria Letizia Barreca†, Violetta Cecchetti†, Subhash G. Vasudevan*#$&, and Giuseppe Manfroni*†
• [ASAP] ProBiS H2O MD Approach for Identification of Conserved Water Sites in Protein Structures for Drug Design<xref rid="notes4" ref-type="statement">‡</xref>
  by Marko Jukic?†?, Janez Konc†§, Dus?anka Janez?ic?*?, and Urban Bren*†?

Journal of Natural Products

• [ASAP] Anti-inflammatory <italic toggle="yes">neo</italic>-Clerodane Diterpenoids from <italic toggle="yes">Ajuga pantantha</italic>
  by Bangjian Dong†¶, Xueyuan Yang†¶, Wenpei Liu†, Lijun An†, Xuke Zhang†, Muhetaer Tuerhong‡, Qing Du?, Chunyan Wang§, Munira Abudukeremu‡, Jing Xu*†§#, Dongho Lee?, Ling Shuai†, Namrita Lall?, and Yuanqiang Guo*†
• [ASAP] Direct Identification of a-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility–Mass Spectrometry/Quantum Chemistry Approach
  by Erik Laurini†, Ste´phane Andreani‡, Alain Muselli‡, Sabrina Pricl†?#, and Aura Tintaru*§
• [ASAP] <italic toggle="yes">chiro</italic>-Inositol Derivatives from <italic toggle="yes">Chisocheton paniculatus</italic> Showing Inhibition of Nitric Oxide Production
  by Khan Viet Nguyen†?, Duc Viet Ho†, Hien Minh Nguyen‡, Thao Thi Do§, Kiem Van Phan?^, Hiroyuki Morita?, Jyrki Heina¨ma¨ki?, Ain Raal*?, and Hoai Thi Nguyen*†
• [ASAP] Sulfadiazine Masquerading as a Natural Product from <italic toggle="yes">Scilla madeirensis</italic> (Scilloideae)
  by Luke P. Robertson*†‡, Lindon W. K. Moodie§?, Darren C. Holland?, K. Charlotte Jande´r†, and Ulf Go¨ransson‡
• [ASAP] Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
  by Blake A. Winn†?, Laxman Devkota†?, Bunnarack Kuch†, Matthew T. MacDonough†, Tracy E. Strecker†, Yifan Wang†, Zhe Shi†, Jeni L. Gerberich‡, Deboprosad Mondal†, Alejandro J. Ramirez§, Ernest Hamel#, David J. Chaplin†¶, Peter Davis¶, Ralph P. Mason‡, Mary Lynn Trawick*†, and Kevin G. Pinney*†
• [ASAP] Prenylated Phenolic Compounds from the Aerial Parts of <italic toggle="yes">Glycyrrhiza uralensis</italic> as PTP1B and a-Glucosidase Inhibitors
  by Jing-ran Fan†‡, Yi Kuang†, Ze-yuan Dong†, Yang Yi†, Yan-xia Zhou†, Bin Li†, Xue Qiao*†, and Min Ye*†
• [ASAP] Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete <italic toggle="yes">Favolaschia</italic> Species
  by Jittra Kornsakulkarn†, Somporn Palasarn†, Wilunda Choowong†, Tienthong Thongpanchang‡, Nattawut Boonyuen†§, Rattaket Choeyklin†§, Thitiya Boonpratuang†§, Masahiko Isaka†, and Chawanee Thongpanchang*†
• [ASAP] Structure–Odor Activity Studies on Derivatives of Aromatic and Oxygenated Monoterpenoids Synthesized by Modifying <italic toggle="yes">p</italic>-Cymene
  by Linda Schreiner†‡§, Johannes Bauer†§, Eva Ortner‡, and Andrea Buettner*†‡
• [ASAP] Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus <italic toggle="yes">Chaetomium globosum</italic> MP4-S01-7
  by Weiyi Wang*†?, Jing Yang‡?, Yan-Yan Liao?, Gang Cheng‡, Jing Chen‡, Xiang-Dong Cheng*§, Jiang-Jiang Qin*‡§, and Zongze Shao†
• [ASAP] Synthesis of <italic toggle="yes">Salicaceae</italic> Acetyl Salicins Using Selective Deacetylation and Acetyl Group Migration
  by Dariya A. Romanova†, David L. Avetyan†§, Maxim L. Belyanin†, and Elena V. Stepanova*†‡