Science Feeds

Journal of Medicinal Chemistry

• [ASAP] Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors
  by Anna Maria Trotta, Michela Aurilio, Crescenzo D’Alterio, Caterina Ieranò, Daria Di Martino, Antonio Barbieri, Antonio Luciano, Paolo Gaballo, Sara Santagata, Luigi Portella, Stefano Tomassi, Luciana Marinelli, Deborah Sementa, Ettore Novellino, Secondo Lastoria, Stefania Scala, Margret Schottelius, and Salvatore Di Maro
• [ASAP] Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <italic toggle="yes">In Vivo</italic> Efficacy in Multiple Myeloma
  by Obdulia Rabal, Edurne San José-Enériz, Xabier Agirre, Juan Antonio Sánchez-Arias, Irene de Miguel, Raquel Ordoñez, Leire Garate, Estíbaliz Miranda, Elena Sáez, Amaia Vilas-Zornoza, Antonio Pineda-Lucena, Ander Estella, Feifei Zhang, Wei Wu, Musheng Xu, Felipe Prosper, and Julen Oyarzabal
• [ASAP] Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities
  by Rao Song, Wenliang Qiao, Jun He, Jiasheng Huang, Youfu Luo, and Tao Yang
• [ASAP] The Philip S. Portoghese <italic toggle="yes">Journal of Medicinal</italic> <italic toggle="yes">Chemistry</italic>/Division of Medicinal Chemistry Joint Lectureship Awards
  by Craig W. Lindsley(Editor-in-Chief) and Jacob B. Schwarz(MEDI Division Chair)
• [ASAP] Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions
  by Minru Liao, Jin Zhang, Guan Wang, Leiming Wang, Jie Liu, Liang Ouyang, and Bo Liu
• [ASAP] ⁶⁴Cu/¹⁷⁷Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer
  by Yuqian Huang, Zhen Yang, Feng Li, Hong Zhao, Chun Li, Nam Yu, Dale J. Hamilton, and Zheng Li
• [ASAP] Correction to “Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles”
  by Amber Y. S. Balazs, Rodrigo J. Carbajo, Nichola L. Davies, Yu Dong, Alexander W. Hird, Jeffrey W. Johannes, Michelle L. Lamb, William McCoull, Piotr Raubo, Graeme R. Robb, Martin J. Packer, and Elisabetta Chiarparin
• [ASAP] Liven Up That Linker
  by James A. Van Deventer
• [ASAP] Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure
  by Andrei A. Golosov, Alec N. Flyer, Jakal Amin, Charles Babu, Christian Gampe, Jingzhou Li, Eugene Liu, Katsumasa Nakajima, David Nettleton, Tajesh J. Patel, Patrick C. Reid, Lihua Yang, and Lauren G. Monovich
• [ASAP] Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
  by Steven P. Langston, Stephen Grossman, Dylan England, Roushan Afroze, Neil Bence, Douglas Bowman, Nancy Bump, Ryan Chau, Bei-Ching Chuang, Christopher Claiborne, Larry Cohen, Kelly Connolly, Matthew Duffey, Nitya Durvasula, Scott Freeze, Melissa Gallery, Katherine Galvin, Jeffrey Gaulin, Rachel Gershman, Paul Greenspan, Jessica Grieves, Jianping Guo, Nanda Gulavita, Shumet Hailu, Xingyue He, Kara Hoar, Yongbo Hu, Zhigen Hu, Mitsuhiro Ito, Mi-Sook Kim, Scott Weston Lane, David Lok, Anya Lublinsky, William Mallender, Charles McIntyre, James Minissale, Hirotake Mizutani, Miho Mizutani, Nina Molchinova, Koji Ono, Ashok Patil, Mark Qian, Jessica Riceberg, Vaishali Shindi, Michael D. Sintchak, Keli Song, Teresa Soucy, Yana Wang, He Xu, Xiaofeng Yang, Agatha Zawadzka, Ji Zhang, and Sai M. Pulukuri

ACS Medicinal Chemistry Letters

• [ASAP] Discovery of 2,4-1<italic toggle="yes">H</italic>-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors
  by Johan J. N. Veerman, Yorik B. Bruseker, Eddy Damen, Erik H. Heijne, Wendy van Bruggen, Koen F. W. Hekking, Rob Winkel, Christopher D. Hupp, Anthony D. Keefe, Julie Liu, Heather A. Thomson, Ying Zhang, John W. Cuozzo, Andrew J. McRiner, Mark J. Mulvihill, Peter van Rijnsbergen, Birgit Zech, Louis M. Renzetti□, Lee Babiss△, and Gerhard Müller
• [ASAP] Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion
  by Simon Vezina-Dawod, Alicia J. Angelbello, Shruti Choudhary, Kye Won Wang, Ilyas Yildirim, and Matthew D. Disney
• [ASAP] Myeloid Cell Leukemia-1 Inhibitors as Emerging Cancer Treatment
  by Ahmed F. Abdel-Magid
• [ASAP] Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy
  by Liping Zhang, Emily C. Cherney, Xiao Zhu, Tai-an Lin, Johnni Gullo-Brown, Derrick Maley, Kathy Johnston-Allegretto, Lisa Kopcho, Mark Fereshteh, Christine Huang, Xin Li, Sarah C. Traeger, Gopal Dhar, Aravind Anandam, Sandeep Mahankali, Shweta Padmanabhan, Prabhakar Rajanna, Venkata Murali, Thanga Mariappan, Robert Borzilleri, Gregory Vite, John T. Hunt, and Aaron Balog
• [ASAP] Peripherally Crowded Cationic Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy
  by Marie Halaskova, Asma Rahali, Verónica Almeida-Marrero, Miloslav Machacek, Radim Kucera, Bassem Jamoussi, Tomás Torres, Veronika Novakova, Andrés de la Escosura, and Petr Zimcik
• [ASAP] Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and <italic toggle="yes">Let-7</italic>
  by Lydia Borgelt||, Fu Li||, Pascal Hommen||, Philipp Lampe||, Jimin Hwang, Georg L. Goebel, Sonja Sievers, and Peng Wu
• [ASAP] Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors
  by Chunpu Li, Sha-Sha Hu, Lisheng Yang, Min Wang, Jian-Dong Long, Bing Wang, Haozhen Han, Haoran Zhu, Sen Zhao, Jing-Gen Liu, Dongxiang Liu, and Hong Liu
• [ASAP] Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1
  by Dongxing Chen, Guangping Dong, Youchao Deng, Nicholas Noinaj, and Rong Huang
• [ASAP] Identification of Potent Reverse Indazole Inhibitors for HPK1
  by Elsie C. Yu, Joey L. Methot, Xavier Fradera, Charles A. Lesburg, Brian M. Lacey, Phieng Siliphaivanh, Ping Liu, Dustin M. Smith, Zangwei Xu, Jennifer A. Piesvaux, Shuhei Kawamura, Haiyan Xu, J. Richard Miller, Mark Bittinger, and Alexander Pasternak
• [ASAP] Reactivation of the Guardian of the Genome P53: A Promising Strategy for Treatment of Cancer
  by Ahmed F. Abdel-Magid

Journal of Natural Products

• [ASAP] Limonoids from <italic toggle="yes">Guarea guidonia</italic> and <italic toggle="yes">Cedrela odorata</italic>: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D
  by Maria Laura Bellone, Cesar Muñoz Camero, Maria Giovanna Chini, Fabrizio Dal Piaz, Vanessa Hernandez, Giuseppe Bifulco, Nunziatina De Tommasi, and Alessandra Braca□
• [ASAP] Taxonomy Driven Discovery of Polyketides from <italic toggle="yes">Aspergillus californicus</italic>
  by Yaojie Guo, Ling Ding, Simone Ghidinelli, Charlotte H. Gotfredsen, Mercedes de la Cruz, Thomas A. Mackenzie, Maria C. Ramos, Pilar Sánchez, Francisca Vicente, Olga Genilloud, Sonia Coriani, René W. Larsen, Jens C. Frisvad, and Thomas O. Larsen
• [ASAP] Natural Isoflavones and Semisynthetic Derivatives as Pancreatic Lipase Inhibitors
  by Nunzio Cardullo, Vera Muccilli, Luana Pulvirenti, and Corrado Tringali
• [ASAP] Amphiol, an Antifungal Fungal Pigment from <italic toggle="yes">Pseudogymnoascus</italic> sp. PF1464
  by Kohei Fujita, Misa Ikuta, Shinichi Nishimura, Ryosuke Sugiyama, Aya Yoshimura, and Hideaki Kakeya
• [ASAP] Exploring the Chemistry of Alkaloids from Malaysian <italic toggle="yes">Mitragyna speciosa</italic> (Kratom) and the Role of Oxindoles on Human Opioid Receptors
  by Nelson Jeng-Yeou Chear, Francisco León, Abhisheak Sharma, Siva Rama Raju Kanumuri, Grant Zwolinski, Khalil A. Abboud, Darshan Singh, Luis F. Restrepo, Avi Patel, Takato Hiranita, Surash Ramanathan, Aidan J. Hampson, Lance R. McMahon, and Christopher R. McCurdy
• [ASAP] <italic toggle="yes">Agaricus bisporus</italic>-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model
  by Wei Peng, Wenjuan Zhang, Qici Wu, Shunyou Cai, Tingting Jia, Jiarui Sun, Zhichao Lin, Gulimiran Alitongbieke, Yixuan Chen, Yi Su, Jinmei Lin, Lisheng Cai, Yuqin Sun, Yutian Pan, and Yu Xue
• [ASAP] Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A
  by Kimberly S. Taylor, Chen Zhang, Evgenia Glukhov, William H. Gerwick, and Takashi L. Suyama
• [ASAP] Natural Product Based Antibody Drug Conjugates: Clinical Status as of November 9, 2020
  by David J. Newman
• [ASAP] Phytochemical Profiling and Biological Activity of the Australian Carnivorous Plant, <italic toggle="yes">Drosera magna</italic>
  by Edward Owen Norman, Hayden Tuohey, David Pizzi, Milane Saidah, Rachael Bell, Robert Brkljača, Jonathan M. White, Robin B. Gasser, Aya C. Taki, and Sylvia Urban
• [ASAP] NMR-Based Quantum Mechanical Analysis Builds Trust and Orthogonality in Structural Analysis: The Case of a Bisdesmosidic Triglycoside as <italic toggle="yes">Withania somnifera</italic> Aerial Parts Marker
  by Sitaram Bhavaraju, David Taylor, Matthias Niemitz, David C. Lankin, Anton Bzhelyansky, Gabriel I. Giancaspro, Yang Liu, and Guido F. Pauli