Science Feeds

Journal of Medicinal Chemistry

• [ASAP] Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in <italic toggle="yes">Trichomonas vaginalis</italic>
  by Yukiko Miyamoto, Shubhangi Aggarwal, Jeff Joseph A. Celaje, Sozaburo Ihara, Jonathan Ang, Dmitry B. Eremin, Kirkwood M. Land, Lisa A. Wrischnik, Liangfang Zhang, Valery V. Fokin, and Lars Eckmann
• [ASAP] Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002
  by Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Dylan Lloyd, Anthony Altieri, Sujata Basu, Oleg V. Krokhin, Andrew J. Halayko, and Neeloffer Mookherjee
• [ASAP] Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation
  by Vanessa Carle, Yuteng Wu, Rakesh Mukherjee, Xu-Dong Kong, Chloé Rogg, Quentin Laurent, Enza Cecere, Camille Villequey, Madhuree S. Konakalla, Tamara Maric, Christina Lamers, Cristina Díaz-Perlas, Kaycie Butler, Junko Goto, Bernd Stegmayr, and Christian Heinis
• [ASAP] Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1
  by Yuqin Lei, Qi An, Xiao-fei Shen, Min Sui, Chungen Li, Da Jia, Youfu Luo, and Qingxiang Sun
• [ASAP] Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection
  by Qi Li, Ying Chen, Shuaishuai Xing, Qinghong Liao, Baichen Xiong, Yuanyuan Wang, Weixuan Lu, Siyu He, Feng Feng, Wenyuan Liu, Yao Chen, and Haopeng Sun
• [ASAP] Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors
  by Niklas M. Tormählen, Mariella Martorelli, Annette Kuhn, Florian Maier, Jamil Guezguez, Michael Burnet, Wolfgang Albrecht, Stefan A. Laufer, and Pierre Koch
• [ASAP] Kinase Inhibitors as Underexplored Antiviral Agents
  by Javier García-Cárceles, Elena Caballero, Carmen Gil, and Ana Martínez
• [ASAP] Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells
  by Anastasiia Priss, Kseniia Afitska, Maksym Galkin, Dmytro A. Yushchenko, and Volodymyr V. Shvadchak
• [ASAP] RGD-Peptide Functionalization Affects the <italic toggle="yes">In Vivo</italic> Diffusion of a Responsive Trimeric MRI Contrast Agent through Interactions with Integrins
  by Giuseppe Gambino, Tanja Gambino, Liam Connah, Francesca La Cava, Henry Evrard, and Goran Angelovski
• [ASAP] Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure–Activity Relationships
  by Vladimir Burmistrov, Rahul Saxena, Dmitry Pitushkin, Gennady M. Butov, Fung-Lung Chung, and Monika Aggarwal

ACS Medicinal Chemistry Letters

• [ASAP] Novel Fragment-Based Screening Method to Identify Small Molecules That Selectively Bind RNA
  by Ram W. Sabnis
• [ASAP] PROTAC-Mediated Degradation of Janus Kinase as a Therapeutic Strategy for Cancer and Rheumatoid Arthritis
  by Robert B. Kargbo
• [ASAP] Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers
  by Eline Sijbesma, Kenneth K. Hallenbeck, Sebastian A. Andrei, Reanne R. Rust, Joris M. C. Adriaans, Luc Brunsveld, Michelle R. Arkin, and Christian Ottmann
• [ASAP] Targeting IRAK1 for Degradation with PROTACs
  by Robert B. Kargbo
• [ASAP] SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
  by Haibin Zhou, Longchuan Bai, Renqi Xu, Donna McEachern, Krishnapriya Chinnaswamy, Ruiting Li, Bo Wen, Mi Wang, Chao-Yie Yang, Jennifer L. Meagher, Duxin Sun, Jeanne A. Stuckey, and Shaomeng Wang
• [ASAP] Structure–Activity Relationship for the Picolinamide Antibacterials that Selectively Target <italic toggle="yes">Clostridioides difficile</italic>
  by Enrico Speri, Yuanyuan Qian, Jeshina Janardhanan, Cesar Masitas, Elena Lastochkin, Stefania De Benedetti, Man Wang, Valerie A. Schroeder, William R. Wolter, Allen G. Oliver, Jed F. Fisher, Shahriar Mobashery, and Mayland Chang
• [ASAP] Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay
  by Maho Takioku, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Shoya Yamada, Mayu Kawasaki, Sohei Ito, Shogo Nakano, and Hiroki Kakuta
• [ASAP] Novel Substituted Thiadiazoles as Splicing Modulators for Modulating Splicing of mRNA and Uses Thereof for Treating Diseases
  by Ram W. Sabnis
• [ASAP] Novel Substituted Pyrazines as Splicing Modulators for Modulating Splicing of mRNA and Uses Thereof for Treating Diseases
  by Ram W. Sabnis
• [ASAP] Novel Heteroaryl Compounds as Splicing Modulators for Modulating Splicing of mRNA and Uses Thereof for Treating Diseases
  by Ram W. Sabnis

Journal of Natural Products

• [ASAP] Efophylins A and B, Two <italic toggle="yes">C</italic>₂-Asymmetric Macrodiolide Immunosuppressants from <italic toggle="yes">Streptomyces malaysiensis</italic>
  by Jing Xu, Xuexia Zhang, Fanglu Huang, Gang Li, and Peter F. Leadlay
• [ASAP] Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors
  by Arun K. Ghosh, Jennifer L. Mishevich, and Melissa S. Jurica
• [ASAP] Water-Soluble Heliomycin Derivatives to Target i-Motif DNA
  by Alexander S. Tikhomirov, Mahmoud A. S. Abdelhamid, Georgy Y. Nadysev, George V. Zatonsky, Eugene E. Bykov, Pin Ju Chueh, Zoë A. E. Waller, and Andrey E. Shchekotikhin
• [ASAP] Cytotoxic Compounds from the Stem Bark of Two subsp. of <italic toggle="yes">Bersama abyssinica</italic>
  by Divinah K. Nyamboki, Kibrom G. Bedane, Khadija Hassan, Lukas Brieger, Carsten Strohmann, Michael Spiteller, and Josphat C. Matasyoh
• [ASAP] Oshimalides A and B, Sesterterpenes of the Manoalide Class from a <italic toggle="yes">Luffariella</italic> sp. Deep-Sea Marine Sponge: Application of Asymmetric Dihydroxylation in Structure Elucidation
  by Daichi Kanki, Ken Imai, Yuji Ise, Shigeru Okada, and Shigeki Matsunaga
• [ASAP] Immunosuppressive 9,10-Secosteroids from the Gorgonian <italic toggle="yes">Verrucella umbraculum</italic> Collected in the South China Sea
  by Jiao Li, Yun-Lei Sun, Hua Tang∧, Li Su∧, Gui-Liang Zheng, and Wen Zhang
• [ASAP] Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1–IL-1β Axis
  by Chang Liu, Huifang Li, Feng Xu, Xian Jiang, Hang Ma, and Navindra P. Seeram
• [ASAP] Synthesis and Biological Activity of Triterpene–Coumarin Conjugates
  by Karina Vega-Granados, Marta Medina-O’Donnell, Francisco Rivas, Fernando J. Reyes-Zurita, Antonio Martinez, Luis Alvarez de Cienfuegos, Jose A. Lupiañez, and Andres Parra
• [ASAP] Cryptic Biosynthesis of the Berkeleypenostatins from Coculture of Extremophilic <italic toggle="yes">Penicillium</italic> sp.
  by Andrea A. Stierle, Donald B. Stierle, Daniel Decato, Jeremy Alverson, and Lily Apedaile
• [ASAP] Tulipiferamide A, an Alkamide from <italic toggle="yes">Liriodendron tulipifera</italic>, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation
  by InWha Park, Hee Sun Byun, Gang Min Hur, and MinKyun Na