ASAP Science Feeds

Journal of Medicinal Chemistry

• Discovery of F73, a New Generation RET Inhibitor Overcoming RET Gatekeeper (V804M) and Solvent-Front (G810C/R) Mutations
  by Gangpeng Yang, Xiaowen Niu, Xiaoxu Zhao, Mingjin Xu, Tingyao Li, Li Tan, Haowen Ma, Zhang Zhang, and Qian Cai
• Broad-Spectrum Antimicrobial Peptide Designed from the Mycobacterium tuberculosis Adenylate Kinase Structure, Inspired by Its LPS/LTA Dual Recognition
  by Chae Yeong Lee, Hyunjoon Cho, Junho Jeong, Kyusung Chae, Eunha Hwang, Eunhee Kim, Myeong Seon Jeong, and Yangmee Kim
• Lipid-Modified CGRP Receptor Antagonists: Balancing Pharmacokinetic Improvement and Potency Loss
  by Adam L. Schofield, Mária Rožňovcová, Vera D’Aloisio, Ryan K. Y. Tan, Gillian A. Hutcheon, Graeme S. Cottrell, and Christopher R. Coxon
• Autonomous Drug Design via Workflow Agents: Integrating Chemical Semantics and Tool-Oriented Automation
  by Jingxuan Ge, Youqiao Qian, Hao Luo, Chang-Yu Hsieh, Hui Shi, Jian Wu, Peichen Pan, Yu Kang, and Tingjun Hou
• Potent and Selective Caspase-2 Inhibitors: Biological Profiling, Structural Characterization, and Challenges of Molecular Instability
  by Lisa Forster, Bernadette Vallaster, Alexander Hubmann, Merlin Bresinsky, Jessica L. Fuller, Ke Shi, Ian P. Lapcinski, Peng Liu, Mu Yang, Jessica M. Strasser, Kathryn M. Nelson, Kristen John, Deepti Mudaliar, Lukas Wirth, Jonas Daschner, Herwig Pongratz, Karen H. Ashe, Michael A. Walters, and Steffen Pockes

Journal of Medicinal Chemistry – Current Issue

• Issue Editorial Masthead
• Issue Publication Information
• Developing a Ferric(III) Agent for Targeted Inhibition of Growth and Metastasis of Triple-Negative Breast Cancer Based on Human Serum Albumin by Chemodynamic Therapy-Driven Synergistic Therapy
• Discovery of Thiazolamide-based PI4KIIIβ/HDAC Dual Inhibitors with Potent Activity against Hepatitis C Virus
• Development of DCL1191 as a Potent, Selective and Orally Bioavailable Inhibitor for Autophagy-Associated Transcription Factor EB (TFEB)

Journal of Medicinal Chemistry Letters

• Will the Revolution Be Cyclized?: Using Macrocyclic Peptides to Deliver Oligonucleotides Extrahepaticaly
• Exploring Five-Membered S -Heterocyclic Scaffolds As Novel CaMKIIα Ligands Targeting the Hub Domain

Journal of Natural Products

• Monomeric and Dimeric Abyssomicins from the Endophytic Actinomycete Streptomyces sp. ns5-4 as Neuroprotective Agents
• Precursor-Directed Production of Bis- and Monopyrrole Phenyl Derivatives by Myrothecium verrucaria and Their Cytotoxic Activity