ASAP Science Feeds

Journal of Medicinal Chemistry

• Centromere-Targeting Chimeras for Combating Cancer Drug Resistance
  by Dingpeng Zhang, Zhen Wang, William W. Feng, Wenyun Zhang, Xutong Xue, Yan Xiong, Xing Gao, Hiroyuki Inuzuka, Jeanelle Tsai, Jiaqi Li, Peiqiang Yan, Zhenbo Tu, Joao A. Paulo, H. Ümit Kaniskan, Antoine E. Karnoub, Pasi A. Jänne, Jian Jin, and Wenyi Wei
• Reducing off-Target hERG Activity of First-Generation DCN1-UBE2M Interaction Inhibitors: Design, Synthesis, and Structure−Activity Relationships
  by Tara Man Kadayat, Gaurav Shoeran, Daniel C. Scott, Kristin L. Begley, Jared T. Hammill, Jong Yeon Hwang, Tucker J. Moseley, Ho Shin Kim, Agripina G. Deaciuc, Moeko T. King, Bhuvanesh Singh, Brenda A. Schulman, and R. Kiplin Guy
• Evaluation of Cytotoxic Potential of Water-Soluble Photosensitive Pincer-Copper Complexes
  by Hachina Begum, Babu Venkateshappa, Hirakjyoti Roy, Siddhartha Sankar Ghosh, and Akshai Kumar
• Discovery of a Pyrazine-2-Carboxamide Derivative as a Potent Plasmodium falciparum Inhibitor with Potential for Single-Dose Cure
  by Vanessa M. Marx, Anne-Catherine Mata, Fumiaki Yokokawa, Thomas Kirrane, Richard Huang, Suresh B. Lakshminarayana, Jay Prakash Jain, Judith Straimer, W. Armand Guiguemde, Luying Pei, Upendra Kulkarni, Christopher J. Thompson, Johanna M. Jansen, Patrick S. Lee, Eric J. Martin, Valery R. Polyakov, Nicole Blaquiere, Alexander Burckle, Grace Waldron, Benjamin R. Taft, Erika L. Flannery, Hanna Schulz, Qumber H. Jafri, Katherine Chan, Erika Kim, Harry Cheung, Vida Ahyong, Changbok Lee, Catherine L. Jones, Christopher S. Lunde, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Leyre Pernaute-Lau, Christian Scheurer, Sibylle Sax, Sergio Wittlin, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Dhelio B. Pereira, Philip J. Rosenthal, Roland A. Cooper, Kyra A. Schindler, David A. Fidock, Brice Campo, Simon F. Campbell, Thierry T. Diagana, and Christopher R. Sarko
• FGFR3 Selectivity in Drug Discovery: Biological Rationale, Design Strategies, and Therapeutic Potential
  by Jacqueline H. Starrett, Daniel C. Bensen, Ronald V. Swanson, and Robert L. Hudkins
• Cascade Mono- and Di-Functionalization of Anticancer Diastereomeric Benzoxazole-Ansamycins toward the Development of Highly Potent Hsp90 Inhibitors of Decreased Toxicity in Normal Cells
  by Aleksandra Leśniewska, Adam Buczkowski, Piotr Ruszkowski, Matthew J. Binder, Alison D. Axtman, Wojciech Schilf, Ewelina Smolarz, Krystian Pyta, Maria Gdaniec, Franz J. Bartl, and Piotr Przybylski
• Ligands Targeting α9-Containing Nicotinic Acetylcholine Receptors: Structure−Activity Relationships and Therapeutic Potential in Neuropathic Pain
  by Megan J. Jurek, Christian J. Peters, and Andrew P. Riley

Journal of Medicinal Chemistry – Current Issue

• Issue Publication Information
• Issue Editorial Masthead
• Structure-Affinity and Selectivity of Aryl-Sulfamates as Inhibitors of Carbonic Anhydrase IX
• An Innovative Auto-Antagonistic Multi-Target Strategy: MOR/DOR/NPFFR 2 Agonists Achieve Separation of Analgesia from Side Effects
• Mapping the N/OFQ(1−13)-NH 2 Address Domain to Identify G Protein-Biased NOP Receptor Agonists

Journal of Medicinal Chemistry Letters

• A High-Throughput Screening Platform for the Discovery of Noncovalent Inhibitors of the ISG15–UBA7 Interaction
• Discovery of Pyrazolopyrimidines as Potent and Orally Bioavailable MRGPRX2 Antagonists

Journal of Natural Products

• Lavasamycins, Glycosylated Dihydroxyanthraquinones from Streptomyces barkulensis subsp. lavasanensis Subsp. nov.
• Shape Shifting Proteusin Peptides and Their Multimodal Binding Interactions Underlie RiPP Biosynthesis