Patents

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  1. Balkovec, J. M. and Black, R. M. Process For Reduction of Certain Cyclohexapeptide Compounds, 1992.  US 5,159,059
  2. Balkovec, J. M. Loewe, M. and Mathre, D. M. Process For Phosphate Ester Compounds of Certain Cyclohexapeptides, 1993.  US 5,233,023
  3. Balkovec, J. M. Lipopeptide Compounds, 1994.  US 5,310,726
  4. Hammond, M. L.; Schwartz, R. E. and Balkovec, J. M. Lipopeptide Derivatives, 1994.  US 5,330,973
  5. Balkovec, J. M. and Zambias, R. A. Cyclohexapeptidyl Hydroxypropionyl Compounds, 1994.  US 5,348,940
  6. Hammond, M. L.; Balkovec, J. M. and Mathre, D. J.  Lipopeptide Derivatives, 1994.  US 5,369,093
  7. Balkovec, J. M.; Bouffard, F. A. and Black, R. M. Aza Cyclohexapeptide Compounds, 1994.  WO 9421677-A1
  8. Balkovec, J. M.; Bouffard, F. A. and Black, R. M. Aza Cyclohexapeptide Compounds, 1995.  US 5,378,804
  9. Hammond, M. L.; Schwartz, R. E. and Balkovec, J. M. Lipopeptide Derivatives, 1995.  US 5,385,884
  10. Hammond, M. L.; Schwartz, R. E. and Balkovec, J. M. Lipopeptide Derivatives, 1995.  US 5,386,009
  11. Balkovec, J. M. Lipopeptide Compounds, 1995.  US 5,386,010
  12. Balkovec, J. M.; Black, R. M.; Bouffard, F. A. Aza Cyclohexapeptide Compounds, 1996.  US 5,514,650
  13. Balkovec, J. M.; Bouffard, F. A. and Dropinski, J. F. Aza Cyclohexapeptide Compounds, 1996.  US 5,514,651
  14. Balkovec, J. M.; Bouffard, F. A. and Dropinski, J. F. Aza Cyclohexapeptide Compounds, 1996.  US 5,516,756
  15. Balkovec, J. M. Semisynthetic Lipopeptides, Compositions Containing Said Lipopeptides, and Methods of Use, 1996.  US 5,516,757
  16. Balkovec, J. M.; Bouffard, F. A. and Black, R. M. Antifungal and Anti-Pneumocystis Compounds, Compositions Containing Such Compounds, and Methods of Use, 1996. US 5,541,160
  17. Balkovec, J. M.; Bouffard, F. A.; Dropinski, J. F.; Adefarati, A. A.; Tkacz, J. S. An Improved Process for Preparing Side Chain Derivatives of Cyclohexapeptidyl Lipopeptides, 1997. US 5,646,245
  18. Balkovec, J. M.; Bouffard, F. A. and Hammond, M. L. Aza Cyclohexapeptide Compounds, 1997.  US 5,668,105
  19. Balkovec, J. M.; Bouffard, F. A.; Dropinski, J. F.; Adefarati, A. A.; Tkacz, J. S. Process For Preparing Side Chain Derivatives of Cyclohexapeptidyl Lipopeptides, 1997.  US 5,684,128
  20. Balkovec, J. M.; Bouffard, F. A. and Dropinski, J. F. Cyclohexapeptidyl Aminoalkyl Ethers, 1997.  US 5,741,775
  21. Balkovec, J. M.; Bouffard, F. A.; Black, R. M. Aza Cyclohexapeptide Compounds, 1998.  US 5,792,746
  22. Balkovec, J. M.; Bouffard, F. A. and Dropinski, J. F. Cyclohexapeptidyl Bisamine Compound, Compositions Containing Said Compound and Methods of Use 1998.  US 5,854,212
  23. Balkovec, J. M.; Hammond, M. L. and Zambias, R. A. Cyclohexapeptidyl Propanolamine Compounds, 1999.  US 5,948,753
  24. Balkovec, J. M. Tse, B. Macrolide Antifungal Compounds 1999.  US 5,948,770
  25. Balkovec, J. M.; Tse, B. Sordarin Derivatives 2000.  US 6,040,463
  26. Balkovec, J. M.; Tse, B. Sordarin Derivatives 2000.  US 6,136,853
  27. Balkovec, J. M.; Bouffard, F. A.; Dropinski, J. F.; Zambias, R. A. Cyclohexapeptidyl Amine Compounds 2001.  US 6,268,338
  28. Balkovec, J. M.; Greenlee, M. L.; Olson, S. H. and Rouen, G. P. Substituted Succinic Acid Metallo-Betalactamase Inhibitors and Their Use in Treating Bacterial Infections, 2003.  US 6,630,510
  29. Olson, S.; Balkovec, J. M., Zhu, Y. 11-Beta-Hydroxysteroid Dehydrogenase 1 Inhibitors Useful For The Treatment of Diabetes, Obesity and Dyslipidemia, 2004.  US 6,730,690B2
  30. Waddell, S. T., Santorelli, G. M.; Maletic, M. M.; Leeman, A. H.; Gu, X.; Graham, D. W.; Balkovec, J. M.; Aster, S. D. Triazole Derivatives As Inhibitors of 11-Beta-Hydroxysteroid dehydrogenase-1, 2004.  US 6,849,636B2
  31. Balkovec, J. M. and Tse, B. Antifungal Agents of Sordarin Derivatives, 2005.  US 6,864,278B2
  32. Olson, S.; Balkovec, J. M., Zhu, Y. 11-Beta-Hydroxysteroid Dehydrogenase 1 Inhibitors Useful For The Treatment of Diabetes, Obesity and Dyslipidemia, 2007.  US 7,179,802B2
  33. Ali, A.; Balkovec, J. M.; Graham, D. W. ; Thompson, C. F. ; Qusaishi, N. 1H-Benzo[F]indazoyl-5-yl Derivatives as Selective Glucocorticoid Receptor Modulators, 2007.  US 7,282,591B2
  34. Balkovec, J. M.; Thieringer, R.; Mundt, S. S.; Hermanowski-Vosatka, A.; Graham, D. W.; Patel, G. F.; Aster, S. D.; Waddell, S. T.; Olson, S. H.; Maletic, M. 11-Beta-Hydroxysteroid Dehydrogenase 1 Inhibitors Useful For The Treatment of Diabetes, Obesity and Dyslipidemia, 2007.  US 7,329,683 B2
  35. Waddell, S. T., Santorelli, G. M.; Maletic, M. M.; Leeman, A. H.; Gu, X.; Graham, D. W.; Balkovec, J. M.; Aster, S. D.  Triazole Derivatives As Inhibitors of 11-beta Hydroxysteroid Dehydrogenase-1, 2009.  US 7,504,402 B2
  36. Ali, A.; Balkovec, J. M.; Graham, D. W. ; Thompson, C. F. ; Qusaishi, N. 1H-Benzo[F]indazoyl-5-yl Derivatives as Selective Glucocorticoid Receptor Modulators, 2010.  US 7,625,937 B2
  37. Ali, A.; Balkovec, J. M.; Beresis, R.; Colletti, S. L.; Graham, D. W. ; Patel, G. ; Smith, C. J. Selective Spirocyclic Glucocorticoid Receptor Modulators, 2010.  US 7,662,846 B2
  38. Balkovec, J. M.; Thieringer, R.; Waddell, S. T.  Triazole Derivatives Which Are Smo Antagonists, 2010.  US 7,691,887 B2
  39. Ali, A., Balkovec, J. M.; Graham, D. W.; Greenlee, M. L.; Taylor, G. E. 17-Carbamoyloxy Cortisol Derivatives As Selective Glucocorticoid Receptor Modulators, 2010.  US 7,732,432 B2
  40. Balkovec, J. M.; Bouffard, F. A.; Tse, B.; Dropinski, J.; Meng, D.; Greenlee. M. L.; Peel, M.; Fan, W.; A. Mamai, A.; Liu, H.; Li, K. Antifungal Agents, 2011.  US 7,863,465 B2
  41. Waddell, S. T.; Balkovec, J. M.; Santorelli, G. M.; Leeman, A. H.; Maletic, M.; Gu, X.  Sulfonyl Compounds as Inhibitors of 11-beta-Hydroxysteroid Dehydrogenase-1, 2011.  US 7,915,252 B2
  42. Waddell, S. T.; Balkovec, J. M.; Kevin, N.; Gu, X. Triazole Derivatives as Inhibitors of 11-beta-Hydroxysteroid Dehydrogenase-1, 2011.  US 7,981,910 B2
  43. Waddell, S. T.; Santorelli, G. M.; Maletic, M.; Leeman, A. H.; Gu, X.; Graham, D. W.; Balkovec, J. M.; Aster, S. D.  Triazole Derivatives as Inhibitors of 11-beta-Hydroxysteroid Dehydrogenase-1, 2011.  US 8,026,264 B2
  44. Aster; S. D., Balkovec; J. M., Graham; D. W., Gu; X., Kevin; N. J., Patel; G. F., Ponpipom; M.  Diaryltriazoles as Inhibitors of 11-beta-Hydroxysteroid Dehydrogenase-1, 2012.  US 8,178,546
  45. Balkovec, J. M.; Siliphaivanh, P.; Bouffard, F. A.; Peel, M. R.; Fan, W.; Mamai, A.; Dimick Gray, S. M.  Antifungal Agents, 2012.  US 8,222,255
Patents Pending
  1. Cernak, T.A.; Balkovec, J.M.; Nargund, R.P.; Reiter, M.; Sperbeck, D. M.; Dykstra, K. D.; Yu, Y.; Dreher, S.; Maloney, K. M.; Wu, Z.; DeVita, R.J.; Verras, A. “Spirocyclic Compounds“, 2012.  WO2012009217
  2. Liu, J; Balkovec, J. M.; Krikorian, A. D.; Guiadeen, D.; Yang, G. X.-Q.; Jian, T.; Wu, Z.; Yu, Y.; Nargund, R. P.; Vachal, P.  “Imidazole Derivatives“, 2012.  WO2012044567
  3. Sperbeck, D. M.; DeVita, R. J.; Balkovec, J. M.; Greenlee, M. L.; Wu, Z.; Yu, Y.; Vachal, P.; Zhou, G.; Wu, H.; Kuang, R.; Ting, P.; Aslanian, R. “Imidazole Derivatives“, 2012.  WO2012044569
  4. Liu, J; Balkovec, J. M.; Krikorian, A. D.; Guiadeen, D.; Yang, G. X.-Q.; Jian, T.; Wu, Z.; Yu, Y.; Nargund, R. P.; Vachal, P.; DeVita, R. J.; He, S.; Lai, Z.; Blevis-Bal, R.; Cernak, T. A.; Sperbeck, D. M.; Hong, Q.  “Imidazole Derivatives“, 2012.  WO2012096813
  5. DeVita, R. J.; Hong, Q.; Lai, Z.; Dykstra, K. D.; Yu, Y.; Liu, J.; Sperbeck, D.; Jian, T.; Guiadeen, D.; Xu-Qiang Yang, G.; Wu, Z.; He, S.; Ting, P. C.; Aslanian, R.; Kuethe, J. T.; Balkovec, J. M.; Kuang, R.; Zhou, G.; Wu, H. “Imidazole Derivatives”, 2012.  WO2012164071
  6. Cernak, T.A.; DeVita, R.J.; Yu, Y.; Wu, Z.; Dykstra, K. D.; Verras, A.; Balkovec, J.M.; Whitehead, A. “Bicyclo [2.2.2]Octan-1-ylcarboxylic Acid Compounds as DGAT-1 Inhibitors”, 2013 .  WO2013068328
  7. Graham, T.; Shen, D.-M.; Liu, W.; Wu, Z.; Nargund, R. P.; DeVita, R. J.; Balkovec, J. M.; Yu, Y. “4-Amino-5-Oxo-7,8-Dihydropyrimido[5, 4 -F] [1, 4]Oxazepine Compounds as DGAT1 Inhibitors”, 2013. WO2013068439
  8. Liu, J; Balkovec, J. M.; Krikorian, A. D.; Miller, D.J.; Guiadeen, D.; Yang, G. X.-Q.; Jian, T.; Wu, Z.; Yu, Y.; Nargund, R. P.; Vachal, P.; He, S.; Lai, Z.; Hong, Q.; DeVita, R. J.; Kim, D.; Ting, P. C.  “Imidazole Derivatives”, 2013.  WO2013074387
  9. Hirabayashi, T.; Katsuno, M.; Smith, C. J.; Sherer, E.; Campeau, L.-C.; Balkovec, J.; Greenlee, W. J.; Li, D.; Guo, L.; Chan, T. Y.; Chen, Y.-H.; Chen, Y.; Chackalamannil, S.;Tan, J. Q. “Factor IXa Inhibitors”, 2014.  WO2014099694
  10. Smith, C. J.; Tan, J. Q.; Zhang, T.; Balkovec, J.; Greenlee, W. J.; Guo, L.; Chen, Y.-H.; Chen, Y.; Chackalamannil, S.; Hirabayashi, T.; Katsuno, M. “Factor IXa Inhibitors”, 2014.  WO2014099695
  11. Smith, C. J.; Tan, J. Q.; Zhang, T.; Balkovec, J.; Greenlee, W. J.; Guo, L.; Xu, J.; Chen, Y.-H.; Chen, Y.;  Chackalamannil, S.; Hirabayashi, T.; Nagasue, H.; Ogawa, K.  “Factor IXa Inhibitors”2014.  WO2014120346
  12. Forrest, K. M.; Judice, J. K.; Warren, H. S.; Balkovec, J. M.; Brady, T. P. “Compositions and Methods for the Treatment of Fungal Infections“, 2015.   WO2015035102
  13. Judice, J. K.; Forrest, K. M.; Warren, H. S.; Balkovec, J. M.; Chen, Z.-y. “Compositions and Methods for the Treatment of Fungal Infections“, 2015. WO2015164289