Publications

  1. Trost,* B. M.; Balkovec, J. M.; Mao, M. K. T.; “A Biomimetic Approach to Plumericin” J. Am. Chem. Soc. 1983, 105, 6755-7.
  2. Trost,* B. M.; Balkovec, J. M.; “The Total Synthesis of Allamandin” Tetrahedron Lett. 1985, 26, 1807-10.
  3. Balkovec, J. M.; “Studies in the Synthesis of Cyclopentanoid Natural Products.  I.  The Total Synthesis of the Iridoids Allamcin, Plumericin and Allamandin.  II. Approach Toward the Total Synthesis of 2b-Hydroxyjatrophone”, Ph.D. Thesis, Univ. Wisconsin, Madison, WI, USA 1985.
  4. Trost,* B. M.; Balkovec, J. M.; Angle, S. R. “Synthesis of 4-Methylene-cyclopentenes” Tetrahedron Lett. 1986, 27, 1445-8.
  5. Trost,* B. M.; Belletire, J. L.; Godleski, S.; McDougal, P. G.; Balkovec, J. M.; Baldwin, J. J.; Christy, M. E.; Ponticello, G. S.; Varga, S. L.; Springer, J. P.; “On the Use of the O-Methylmandelate Ester For Establishment of Absolute Configuration of Secondary Alcohols” J. Org. Chem. 1986, 51, 2370-4.
  6. Trost,* B. M.; Mao, M. K. T.; Balkovec, J. M.; Buhlmayer, P.; “A Total Synthesis of Plumericin, Allamcin, and Allamandin.  Part 1.  Basic Strategy” J. Am. Chem. Soc.  1986, 108, 4965-73.
  7. Trost,* B. M.; Balkovec, J. M.; Mao, M. K. T.; “A Total Synthesis of Plumericin, Allamcin and Allamandin.  Part 2.  A Biomimetic Strategy” J. Am. Chem. Soc. 1986, 108, 4974-83.
  8. Balkovec,* J. M.; Szymonifka, M. J.; Heck, J. V.; Ratcliffe, R. W. “Basic Carbapenem Analogs:  Synthesis And In Vitro Activity of 1b-Methyl-2-(Pyridylmethylthio)-Carbapenems” J. Antibiot. 1991, 44, 1172-77.
  9. Balkovec,* J. M.; Black, R. M.; Hammond, M. L.; Heck, J. V.; Zambias, R. A.; Abruzzo, G.; Bartizal, K.; Kropp, H.; Trainor, C.; Schwartz, R. E.; McFadden, D. C.; Nollstadt, K. H.; Pittarelli, L. A.; Powles, M. A.; Schmatz, D. M. “Synthesis, Stability and Biological Evaluation of Water Soluble Prodrugs of a New Echinocandin Lipopeptide.  Discovery of a Potential Clinical Agent for the Treatment of Systemic Candidiasis and Pneumocystis carinii Pneumonia (PCP)” J. Med. Chem. 1992, 35, 194-8.
  10. Schmatz,* D. M.; Powles, M. A.; McFadden, D. C.; Pittarelli, L.; Balkovec, J.; Hammond, M.; Zambias, R.; Liberator, P.; Anderson, J. “Antipneumocystis Activity of Water-Soluble Lipopeptide L-693,989 in Rats” Antimicrob. Agents and Chemother. 1992, 36, 1964-70.
  11. Bartizal,* K.; Abruzzo, G.; Trainor, C.; Krupa, D.; Nollstadt, K.; Schmatz, D.; Schwartz, R.; Hammond, M.; Balkovec, J.; VanMiddlesworth, F. “In Vitro Antifungal Activity and In Vivo Efficacy of 1,3-b-D-Glucan Synthesis Inhibitors, L-671,329, L-646,991, Tetrahydroechinocandin B and a Papulacandin L-687,781” Antimicrob. Agents and Chemother. 1992, 36, 1648-57.
  12. Balkovec,* J. M.; Black, R. M. “Reduction Studies of Antifungal Echinocandin Lipopeptides.  One Step Conversion of Echinocandin B to Echinocandin C” Tetrahedron Lett. 1992, 33, 4529-32.
  13. Schmatz,* D. M.; Abruzzo, G.; Powles, M. A.; McFadden, D. C.; Balkovec, J. M.; Black, R. M.; Nollstadt, K.; Bartizal, K.  “Pneumocandins from Zalerion arboricola.  IV. Biological Evaluation of Natural and Semisynthetic Pneumocandins for Activity Against Pneumocystis carinii and Candida Species”  J. Antibiot. 1992, 45, 1886-91.
  14. Heck,* J. V.; Balkovec, J. M.; Black, R.; Hammond, M. L.; Zambias, R. “Synthesis and Structure-Activity Relationships of Echinocandin Antifungal Agents” In Antibiotics and Antiviral Compounds:  Chemical Synthesis and Modification; Krohn, K., Kirst, H. A., and Maag, H. Eds.; VCH Publishers Inc.:  New York; 1993; pp 153-9.
  15. Balkovec,* J. M.; Black, R. M. Abruzzo, G., Bartizal, K., Dreikorn, S. and Nollstadt, K. “Structure-Activity Studies of the Pneumocandin Antifungal Lipopeptides.  The Phenolic Hydroxyl is Required For 1,3-b-Glucan Synthesis Inhibition”  Bioorg. Med. Chem. Lett. 1993, 3, 2039-42.
  16. Bouffard,* F. A.; Zambias,* R. A.; Dropinski, J. F.; Balkovec, J. M.; Hammond, M. L.; Abruzzo, G. K.; Bartizal, K. F.; Marrinan, J. A.; Kurtz, M. B.; McFadden, D. C.; Nollstadt, K. H.; Powles, M. A.; Schmatz, D. M. “Synthesis and Antifungal Activity of Novel Cationic Pneumocandin B0 Derivatives” J. Med. Chem. 1994, 37, 222-5.
  17. Balkovec, J. M. “Lipopeptide Antifungal Agents” Expert Opin. Invest. Drugs 1994, 3, 65-82.
  18. Kurtz,* M. B.; Douglas, C.; Marrinan, J.; Nollstadt, K.; Onishi, J.; Dreikorn, S., Milligan, J.; Mandala, S.; Thompson, J.; Balkovec, J. M.; Bouffard, F. A.; Dropinski, J. F.; Hammond, M. L.; Zambias, R. A.; Abruzzo, G.; Bartizal, K.; McManus, O. B.; Garcia, M. L. “Increased Antifungal Activity of L-733,560, A Water Soluble Semisynthetic Pneumocandin, is Due to Enhanced Inhibition of Cell Wall Synthesis” Antimicrob. Agents and Chemother. 1994, 38, 2750-7.
  19. Zambias, R. A.; James, C.; Hammond, M. L.; Abruzzo, G. K.; Bartizal, K. F.; Nollstadt, K. H.; Douglas, C.; Marrinan, J.; Balkovec,* J. M. “Antifungal Lipopetides:  Structure-Activity Relationships of 3-Hydroxyglutamine-Modified Pneumocandin B0 Derivatives” Bioorg. Med Chem. Lett. 1995, 5, 2357-62.
  20. Tse,* B.; Blazey, C. M.; Tu, B.; Balkovec, J. “Determination of the Absolute Stereochemistry of (-)-Galbonolide A” J. Org. Chem. 1997, 62, 3236-3241.
  21. Zambias, R. A.; James, C.; Abruzzo, G. K.; Bartizal, K. F., Hajdu, R.; Thompson, R.; Nollstadt, K.; Marrinan, J.; Balkovec,* J. M. “Lipopeptide Antifungal Agents:  Amine Conjugates of the Semi-Synthetic Pneumocandins L-731,373 and L-733,560” Bioorg. Med Chem. Lett. 1997, 7, 2021-6.
  22. Balkovec,* J. M.; Black, R. M.; Bouffard, F. A.; Dropinski, J. F.; Hammond, M. L. in “The Fungal Cell Wall as a Drug Discovery Target:  SAR of Novel Echinocandin Analogs” Proceedings of the XIVth International Symposium on Medicinal Chemistry, F. Awouters (Ed.), Elsevier Science B. V., 1997.
  23. Bartizal,* K.; Gill, C. J.; Abruzzo, G.; Flattery, A. M.; Kong, L.; Scott, P. M.; Smith, J. G.; Leighton, C. E.; Bouffard, A.; Dropinski, J. F.; Balkovec, J. M. “In Vitro Preclinical Evaluation Studies with Echinocandin Antifungal MK-0991 (L-743,872)” Antimicrob. Agents and Chemother. 1997, 41, 2326-32.
  24. Abruzzo,* G.; Flattery, A. M.; Gill, C. J.; Kong, L.; Smith, J. G.; Pikounis, V. B.; Balkovec, J. M.; Bouffard, F. A.; Dropinski, J. F.; Rosen, H.; Kropp, H.; Bartizal, K. “Evaluation of Echinocandin Antifungal MK-0991 (L-743,872) Efficacy in Mouse Models of Disseminated Aspergillosis, Candidiasis and Cryptococcosis” Antimicrob. Agents and Chemother. 1997, 41, 2333-8.
  25. Black,* R. M.; Balkovec, J. M.; Dreikorn, S.; Nollstadt, K. M.; Bartizal, K. F.; Abruzzo, G. K. “Synthesis and Structure-Activity Relationships of Novel 3’-Hty-Substituted Pneumocandins” Bioorg. Med Chem. Lett. 1997, 7, 2879-84.
  26. Justice, M. C.; Hsu, M.-J.; Tse, B.; Ku, T.; Balkovec, J.; Schmatz, D.; Nielsen,* J. “Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis” J. Biol. Chem. 1998, 273, 3148-51.
  27. Powles,* M. A., Liberator, P., Anderson, J., Karkhanis, Y., Dropinski, J. F., Bouffard, F. A., Balkovec, J. M., Fujioka, H., Aikawa, M., McFadden, D. and Schmatz, D.  “Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models of Pneumocystis carinii” Antimicrob. Agents and Chemother. 1998, 42, 1985-9.
  28. Tse,* B.; Balkovec, J. M.; Blazey, C. M.; Hsu, M.-J.; Nielsen, J.; Schmatz, D. “Alkyl Side-Chain Derivatives of Sordaricin as Potent Antifungal Agents Against Yeast” Bioorg. Med. Chem. Lett. 1998, 8, 2269-72.
  29. Balkovec,* J. M. “Non-Azole Antifungal Agents” Ann. Reports Med. Chem. 1998, 33, 173-82.
  30. Greenlee,* M. L.; Laub, J. B.; Balkovec, J. M.; Hammond, M. L.; Hammond, G. G.; Pompliano, D. L.; Epstein-Toney, J. H. “The discovery and synthesis of potent thiol and thioester inhibitors of the IMP-1 metallo-b-lactamase” Bioorg. Med. Chem. Lett. 1999, 9, 2549-52.
  31. Hammond,* G. G.; Huber, J. L.; Greenlee, M. L.; Laub, J. B.; Young, K.; Silver, L. L.; Balkovec, J. M.; Pompliano, D. L.; Epstein-Toney, J. H. “Inhibition of IMP-1 metallo-b-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives” FEMS Microb. Lett., 1999, 179, 289-96.
  32. Stork,* G.; Niu, D.; Fujimoto, R.; Koft, E. R.; Balkovec, J. M.; Tata, J. and Dake, G. R. “The first stereoselective total synthesis of quinine” J. Am. Chem. Soc. 2001, 123, 3239-42.
  33. Toney,* J. H.; Hammond, G. G.; Fitzgerald, P. M. D.; Sharma, N.; Balkovec, J. M. , Rouen, G. P.; Olson, S. H.; Hammond, M. L.; Greenlee M. L.; Gao, Y.-D. “Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase” J. Biol. Chem., 2001, 276, 31913- 18.
  34. Ali,* A; Thompson, C. F.; Balkovec, J. M.; Graham, D. W.; Hammond, M. L.; Quraishi, N.; Tata, J. R.; Einstein, M.; Ge, L.; Harris, G.; Kelly, T. M.; Mazur, P.; Pandit, S.; Santoro, J.; Sitlani, A.; Wang, C.; Williamson, J.; Miller, D. F.; Thompson, C. M.; Zaller, D. M.; Forrest, M. J.;  Carballo-Jane E. and Luell, S. “Novel N-Arylpyrazolo[3,2-c] Based Ligands for the Glucocorticoid Receptor: Receptor Binding and In-Vivo Activity” J. Med. Chem., 2004, 47, 2441 – 52.
  35. Einstein,* M.; Greenlee, M. L.; Rouen, G. P.; Sitlani, A.; Santoro, J. C.; Wang, C.; Pandit, S.; Mazur, P.; Smalera, I. T.; Zeng, Y. Y.; Kelly, T. M.; Paiva, A. M.; Geissler, W. M.; Mosley, R. T.; Williamson, J. M.; Balkovec, J. M.; Ali, A. and Harris, G. S. “Novel glucocorticoid receptor selective nonsteroidal ligands antagonize the action of enzymes involved in gluconeogenesis and glutamine metabolism in vitro” J. Steroid Biochem. Mol. Biol., 2004, 92, 345 – 56.
  36. Thompson,* C. F.; Quraishi, N.; Ali, A.; Tata, J. R.; Hammond, M. L.; Balkovec, J. M.; Einstein, M.; Ge, L.; Harris, G.; Kelly, T. M.; Mazur, P.; Pandit, S.; Santoro, J.; Sitlani, A.; Wang, C.; Williamson, J.; Miller, D. K.; Thompson, C. M.; Zaller, D. M.; Forrest, M. J.; Carballo-Jane, E.; Luell, S. “Novel Heterocyclic Glucocorticoids: In Vitro Profile And In Vivo Efficacy” Bioorg. Med Chem. Lett. 2005, 15, 2163-67.
  37. Smith,* C. J.; Ali, A.; Balkovec, J. M.; Graham, D. W.;  Hammond, M. L.; Patel, G. F.; Rouen, G.; Smith, S. K.; Tata, J. R.; Einstein, M.; Ge, L.; Harris, G.; Kelly, T. M.; Mazur, P.; Thompson, C. M.; Wang, C. F.; Williamson, J.; Miller, D. K.; Pandit, S.; Santoro, J. C.; Sitlani, A.; Yamin, T.-T. D.; O’Neill, E. A.; Zaller, D. M.; Carballo-Jane, E.; Forrest, M. J.;  Luell, S.  “Novel Ketal Ligands for the Glucocorticoid Receptor: In Vitro and in Vivo Activity” Bioorg. Med Chem. Lett. 2005, 15, 2926-31.
  38. Olson,* S.H.; Aster, S. D.; Brown, K.; Carbin, L.; Graham, D. W.; Hermanowski-Vosatka,* A.; Legrand, C. B.; Mundt, S. S.; Robbins, M. A.; Schaeffer, J. M.; Slossberg, L.; Szymonifka, M. J.; Thieringer, R.; Wright, S. D.; Balkovec, J. M. “Adamantyl triazoles As Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1” Bioorg. Med Chem. Lett. 2005, 15, 4359-62.
  39. Hermanowski-Vosatka,* A.; Balkovec, J. M.; Cheng, K.; Chen, H. Y.; Frazier, E.; Hernandez, M.; LeGrand, C. B.; Liu, Z.; Metzger, J. M.; Mundt, S. M.; Noonan, H.; Nunes, C. N.; Olson, S. H.; Pikounis, B.; Ren, N.; Robertson, N.; Schaeffer, J. M.; Springer, M. S.; Strack, A. M.; Strowski, M.; Wright, S. D.; Wu, K.; Wu, T.-J.; Zhang, B. B. and Thieringer, R. “11β-HSD1 Inhibition Ameliorates Metabolic Syndrome and Prevents Progression of Atherosclerosis in Mice” J. Exp. Med., 2005, 202, 517-27.
  40. Gu,* X.; LeGrand, C.; Dragovic, J.; Shah, K.; Mundt, S. S.;.Koo, G. C.; Zokian, H. J.; Thieringer, R.; Hermanowski-Vosatka, A.; Springer, M.; Balkovec, J. M.; Waddell, S. T. “Discovery of 4-Heteroarylbicyclo[2.2.2]octyltriazoles as Potent and Selective Inhibitors of 11β-HSD1:  Novel Therapeutic Agents for the Treatment of Metabolic Syndrome” Bioorg. Med. Chem. Lett. 2005, 15, 5266-69.
  41. Gao,* Y.-D.; Olson, S. H.; Balkovec, J. M.; Zhu, Y.; Royo, I.; Tang, W.; Tan, E.; Evers, R.; Mosley, R. T. “Attenuating PXR Activation: A Molecular Modeling Approach” Xenobiotica 2007, 37, 124-38.
  42. Thompson,* C. F.; Quraishi, N.; Ali, A.; Mosley, R.T., Tata, J. R.; Hammond, M. L.; Balkovec, J. M.; Einstein, M.; Ge, L.; Harris, G.; Kelly, T. M.; Mazur, P.; Pandit, S.; Santoro, J.; Sitlani, A.; Wang, C.; Williamson, J.; Miller, D. K.; Yamin, T.-T. D.; Thompson, O’Neill, E. A.; C. M.; Zaller, D.M., Forrest, M.J., Carballo-Jane, E., Luell, S. Novel Glucocorticoids Containing a 6,5-Bicyclic Core Fused to a Pyrazole Ring:  Synthesis, In Vitro Profile, molecular modeling studies, and in vivo experiments” Bioorg. Med. Chem. Lett. 2007, 17, 3354-61.
  43. Aster,* S. A.; Graham, D. W.; Kharbanda, D.; Patel, G.; Santorelli, G. M.; Szymonifka, M. J.; Mundt, S. S.; Shah, K.; Springer, M. S.; Thieringer, R.; Hermanowski-Vosatka, A.; Wright, S. D.; Xiao, J.; Zokian, H.; Balkovec, J. M. “Bis-Aryl Triazoles As Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase type 1” Bioorg. Med. Chem. Lett. 2008, 18, 2799-2804
  44. Zhu,* Y.; Olson, S.H.; Hermanowski-Vosatka, A.; Mundt, S.S.; Shah, K.; Xiao, J.; Gao, Y.; Springer, M.S.; Thieringer, R.; Wright, S.D.; Zokian, H.J.; Balkovec, J.M. “4-Methyl-5-Phenyl Triazoles as Selective Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type I” Bioorg. Med. Chem. Lett. 2008, 18, 3405-11.
  45. Zhu,* Y.; Olson, S.H.; Hermanowski-Vosatka, A.; Mundt, S.S.; Shah, K.; Springer, M.S.; Thieringer, R.; Wright, S.D.; Xiao, J.; Zokian, H.J.; Balkovec, J.M. “Phenylcyclobutyl Triazoles as Selective Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type I” Bioorg. Med. Chem. Lett. 2008, 18, 3412-16.
  46. Ali,* A.; Balkovec, J. M.; Greenlee, M.; Hammond, M. L.; Rouen, G.; Taylor, G.; Einstein, M.; Ge, L.; Harris, G.; Williamson, J.; Kelly, T. M.; Mazur, P.; Pandit, S.; Santoro, J.; Sitlani, A.; Wang, C.; Forrest, M. J.; Carballo-Jane, E.; Luell, S.; Du, F.; Lowitz, K.; Visco, D. “Discovery of Betamethasone 17α-Carbamates As Fully Dissociated Glucocorticoid Receptor Modulators In The Rat” Bioorg. Med. Chem. Lett. 2008, 18, 7535-42.
  47. Sun,* W.; Maletic, M.;  Mundt, S. S.;  Shah, K.; Zokian, H.; Lyons, K.; Waddell, S. T.;  Balkovec, J. M. ” Substituted Phenyl Triazoles as Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1″ Bioorg. Med. Chem. Lett. 2011, 21, 2141-5.
  48. Maletic,* M.; Leeman, A.; Szymonifka, M.; Mundt, S. S.; Zokian, H. J.; Shah, K.; Dragovic, J.; Lyons, K.; Thieringer, R.; Vosatka, A. H.; Balkovec, J.; Waddell, S. T “Bicyclo[2.2.2]octyltriazole Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type I.  Pharmacological Agents for the Treatment of Metabolic Syndrome” Bioorg. Med. Chem. Lett. 2011, 21, 2568–72.
  49. McLaren,* D.G.; He, T.Y., Wang, S.; Rosa, R.A.; Gagen, K.; Bhat, G.; Herath, K.B.; Miller, P.; Strack, A.M.; Stribling, D.S.; Taggart, A.K.P.; Imbriglio, J.E.; Liu, J.; Chen, D.; Pinto, S.; Balkovec, J.M.; DeVita, R.J.; Marsh, D.J.; Castro-Perez, J.M.; Previs, S.; Johns, D.G.; Hubbard, B.K.; Roddy, T.P. “The Use of Stable-Labeled Oleic Acid to Interrogate Lipid Assembly and Substrate Partitioning In Vivo with Rapid Analysis by LC-MS”  J. Lipid Res. 2011, 52, 1150-61.
  50. Cernak,* T.A.; Dykstra, K.D.; Verras, A., LeVorse, D.A., Balkovec, J.M., Nargund, R.P., DeVita, R.J. “Synthesis of oxaspiropiperidines as a strategy for lowering logD” Tetrahedron Lett. 2011, 52, 6457-9.
  51. Heasley, B. H.;* Pacofsky, G. J.; Mamai, A.; Liu, H.; Nelson, K.; Coti, G.; Peel, M. R.; Balkovec, J. M.; Greenlee, M. L.; Liberator, P.; Meng, D., Parker, D. L.; Wilkening, R. R.; Apgar, J. M.; Racine, F., Hsu, M. J.; Giacobbe, R. A.; Nielsen-Kahn, J. “Synthesis and Biological Evaluation of Antifungal Derivatives of Enfumafungin as Orally Bioavailable Inhibitors of β-1,3-Glucan Synthase” Bioorg. Med. Chem. Lett. 2012, 22, 6811-16
  52. Luo,* M.J.; Thieringer, R.; Springer, M.S.; Wright, S.D.; Hermanowski-Vosatka, A.; Plump, A.; Balkovec, J.M.; Cheng, K.; Ding, G. J.; Kawka, D.W.; Koo, G.C.; Le Grand, C.B.; Luo, Q.; Maletic, M.M.; Malkowitz, L.; Shah, K.; Singer, I.; Waddell, S.T.; Wu, K.K.; Yuan, J.; Zhu, J.; Stepaniants, S.; Yang, X.; Lum, P.; Wang, I.-M. “Comprehensive gene expression profiling studies reveal suppression of vascular inflammation in a mouse model of atherosclerosis after 11β-HSD1 inhibition” Physiol. Genomics 2013, 45, 47-57.
  53. Liu, J.;  Gorski, J.; Gold, S.; , Chen, D.;  Chen, S.; Forrest, G.; Itoh, Y.; Marsh, D.;  McLaren, D.; Shen, Z.; Sonatore, L.; Lisnock, JM;  Carballo-Jane, E.; Craw, S.; Guan, X.; Karanam, B.; Sakaki, J.; Szeto; D.; Tong, X.; Xiao, J.; Yoshimoto, R.; Yu, H.; Balkovec, J.; Pinto, S.* “Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release – potential insight into mechanism of action” Obesity 2013, 21, 1406–15.
  54. He, S.*; Hong, Q.; Lai, Z.; Wu, Z.; Yu, Y.; Kim, D.; Ting, P.; Kuethe, J.; Yang, G.; Jian, T.; Liu, J.; Guiadeen, D.; Krikorian, A.; Sperbeck, D.; Sonatore, L.; Wiltsie, J.; Chung, C.; Gibson, J.; Lisnock, J.; Murphy, B.; Gorski, J.; Liu, J.; Chen, D.; Chen, X.; Wolff, M.; Tong, S.; Madeira, M.; Karanam, B.; Shen, D.-M.; Balkovec, J.; Pinto, S.; Nargund, R.; DeVita, R. “Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety” ACS Med. Chem. Lett. 2013,  4, 773–8.
  55. Balkovec, J. M.; Hughes, D. L.; Masurekar, P. S.; Sable, C. A.; Schwartz, R. E.; Singh, S. B.* “Discovery and Development of Caspofungin (CANCIDAS®)- Concept to Clinic” in Natural Products: Discourse, Diversity and Design (Book Chapter in press), 2013.
  56. Balkovec, J. M.; Hughes, D. L.; Masurekar, P. S.; Sable, C. A.; Schwartz, R. E.; Singh, S. B.* “Discovery and Development of First in Class Antifungal Caspofungin (CANCIDAS®) – A Case Study” Nat. Prod. Rep., 2014, 31, 15-34.
  57. He, S.*; Hong, Q.; Lai, Z.; David, X. Yang, Ting, P.; Kuethe, J.; Cernak, T. A.; Dykstra, K. D.; Sperbeck, D.; Wu, Z.; Yu Y., Yang, G. X.;  Jian, T., Liu, J., Guiadeen, D.; Krikorian, A. D.;  Sonatore, L. M.; Wiltsie, J.; Chung, C.; Gibson, J.; Lisnock, J.; Murphy, B.; Gorski, J.; Liu, J.; Xiao, J.; Chen, D.; Chen, X.; Wolff, M.; Tong, S.; Madeira, M.; Karanam, B.; Shen, D.-M.; Balkovec, J.; Pinto, S.; Nargund, R.; DeVita, R. “Discovery of DGAT1 Inhibitors in the Benzimidazole Series With a Piperidinyloxy-Cyclohexanecarboxylic acid Moiety” ACS Med. Chem. Lett. 2014, 5, 1082-6.
  58. Parker Jr.,D. L.*;  Walsh, S.; Li, B.; Kim, E.; Sharipour, A.; Smith, C.; Chen, Y.-H.; Berger, R.; Harper, B.; Zhang, T.; Park, M.; Shu, M.; Wu, J.; Xu, J.; Dewnani, S.; Sherer, E. C.; Hruza, A.; Reichert, P.; Geissler, W.; Sonatore, L.; Ellsworth, K.; Balkovec, J.; Greenlee, W.; Wood, H. B. “Rapid development of two factor IXa inhibitors from hit to lead” Bioorg. Med. Chem. Lett., 2015, 25, 2321-5.
  59. Apgar, J. M.*; Wilkening, R. R.; Greenlee, M. L.; Balkovec, J. M.; Flattery, A. M.; Abruzzo, G. K.; Galgocia, A. M.; Giacobbe, R. A.; Gill, C. J.; Hsu, M.-J.; Liberator, P.; Misura, A. S.; Motyl, M.; Nielsen-Kahn, J.; Powles, M.; Racine, F.; Dragovic, J.; Habulihaza, B.; Fan, W.; Kirwan, R.; Lee, S.; Liu, H.; Mamai, A.; Nelson, K.; Peel, M. “Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin” Bioorg. Med. Chem. Lett., 2015, 25, 5813-8.
  60. Ong, V.*; Hough, G.; Schlosser, M.; Bartizal, K.; Balkovec, J.; James, K.; Krishnan, R. “Preclinical Evaluation of the Stability, Safety and Efficacy of CD101, a Novel Echinocandin” Antimicrob. Agents and Chemother. 2016, 60, 6872-9.
  61. Cernak, T.*; Gesmundo, N.; Dykstra, K.; Yu, Y.; Wu, Z.; Shi, Z.-c.; Vachal, P.; Sperbeck, D.; He, S.; Murphy, B.; Sonatore, L.; Williams, S.; Madeira, M.; Verras, A.; Reiter, M.; Lee, C.e; Cuff, J.; Sherer, E.; Kuethe, J.; Goble, S.; Perrotto, N.; Pinto, S.; Shen, D.-M.; Nargund, R. Balkovec, J.; DeVita, R.; Dreher, S. “Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole DGAT1 Inhibitors” J. Med. Chem. 2017, 60, 3594-3605.
  62. Balkovec, J. M. “Advances in Antifungal Drug Development” Med. Chem. Rev. 2018, 53, 313-38.
  63. He, S.; Lai, Z.; Hong, Q.; Shang, J.; Reibarkh, M.; Kuethe, J. T.; Liu, J.; Guiadeen, D.; Krikorian, A. D.; Cernak, T. A.; Dykstra, K. D.; Sperbeck, D. M.; Wu, Z.; Yu, Y.; Yang, G. X.; Jian, T.; Verras, A.; Sonatore, L. M.; Wiltsie, J.; Chung, C. C.; Murphy, B. A.; Gorski, J. N.; Liu, J.; Xiao, J.; Wolff,  M.; Tong, S. X.; Madeira, M.; Karanam, B. V.; Shen, D.-M.; Balkovec, J. M.; Pinto, S.; Nargund, R. P.; DeVita, R. J. “Benzimidazole-Based DGAT1 Inhibitors with a [3.1.0] Bicyclohexane Carboxylic Acid Moiety” Bioorg. Med. Chem. Lett. 2019, 29, 1182-6.
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